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A comparison of the components of the multifocal and full-field ERGs

Conscious visual electrophysiology improves the viability of longitudinal studies by eliminating erg wl-003 associated with repeated anaesthesia. It will also enable uncontaminated assessment of drug effects, allowing the eye to be used as an erg wl-003 biomarker of the central nervous system. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the erg wl-003. The electroretinogram ERG and the visual evoked potential VEP are widely used non-invasive tools in laboratory and clinical settings. A key advantage of the ERG is that the composite waveform can be broken down to components, each reflecting the integrity of particular retinal cell classes [ 12 ]. Of the various stimuli used to elicit the ERG, a full-field flash provides the most comprehensive index of global erg wl-003 function.

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The major components of the flash ERG comprise an initial negative waveform a-wave; photoreceptor response followed by a large positivity b-wave; bipolar cell responsewhich can be further broken down to rod night vision or cone day vision contributions [ 3 ]. Early components of the VEP P1-N1 reflect the integrity of the optic nerve [ 4 ], whereas latter components reflect processing by higher cortical centers P2 onwards [ 56 ]. Hence simultaneous measurement of erg wl-003 ERG and VEP allows comprehensive assessment of different serial elements along the visual pathway.

To date, ERG and VEP measurements in animals require general erg wl-003, which is known to modify body temperature [ 7 ], blood flow [ 8 ] and heart rate [ 9 ]. As anaesthetic compounds exert their sedative and analgesic effects by acting on neurochemical receptors in the central nervous system [ 1011 ], it is not surprising that both retinal [ erg wl-003 ] and cortical [ 13 ] responses are also altered.

This confound greatly limits the use of the erg wl-003 ERG and VEP as biomarkers for preclinical drug testing that target these receptor systems. Other disadvantages of anaesthesia are that it limits the duration of experiments, as prolonged or repeated anaesthesia can lead erg wl-003 perioperative respiratory complications [ 19 ].

More importantly, anaesthetic usage does not replicate conscious clinical recordings. There have been attempts to measure awake ERG and VEPs via tethered setups, however erg wl-003 studies have several shortcomings [ 1120 - 22 ].


Specifically, the use of wire connectors restrict animal movement and natural behaviour leading to stress confounds [ 23 ]. Tang and erg wl-003 [ 24 ] have reported that differences in weight and flexibility of the cables can substantially modify EEG recordings.

Furthermore, wired recordings require externalization of electrodes, which increases the risk of infection. Our study aims to address these shortcomings by developing a novel, wireless, fully enclosed and surgically stable platform for simultaneous ERG and Erg wl-003 measurement in rats.

A comparison of the components of the multifocal and full-field ERGs Donald C. Hood Request PDF

There is also a scarcity of information erg wl-003 longitudinal stability of implanted electrodes [ 21 ], which we aim to address by repeated conscious recordings. Finally, we will investigate the effect of commonly used laboratory anaesthetics ketamine:xylazine or isoflurane on the visual recordings of rats. This methodology has erg wl-003 to improve areas including longitudinal basic research, disease studies as well as preclinical drug evaluation. For all procedures mydriasis was achieved with one drop of both tropicamide 0.

Even illumination of the retina was achieved via a Ganzfeld integrating sphere Photometric Solutions International, Huntingdale, Victoria, Australia as previous [ 26 ]. Signals were collected erg wl-003 a range of luminous energies At the dimmest intensity 80 signals were averaged, with progressively fewer averaged at brighter light levels. Interstimulus interval was progressively lengthened from 1 to seconds from dimmest to the brightest light level. A twin-flash paradigm was presented at the brightest luminous energy to isolate the cone response as detailed in Nixon et al. These authors contributed equally to this work.

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